Paraneoplastic Antibodies Molecular and clinical studies
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چکیده
منابع مشابه
Clinical neuropathology practice guide 5-2012: Updated guideline for the diagnosis of anti-neuronal antibodies
In recent years there is an increasing description of novel anti-neuronal antibodies that are associated with paraneoplastic and non-paraneoplastic neurological syndromes. These antibodies are useful in clinical practice to confirm the immunmediated origin of the neurological disorder and are helpful in tumor search. Currently, antineuronal antibodies can be classified according to the location...
متن کاملAntinuclear antibodies define a subgroup of paraneoplastic neuropathies: clinical and immunological data.
OBJECTIVE Paraneoplastic neuropathy is a clinical and immunological heterogeneous disorder and attempts have been made to classify subgroups of this disease. Only 30-50% of the clinical defined cases have antineuronal antibodies. METHODS The clinical and immunological features of 36 patients with paraneoplastic neuropathy from the authors' database were analysed including the type and course ...
متن کاملAntibodies to a Brain-Type Creatine Kinase: Biomarker of Cancer-Related Paraneoplastic Neurological Syndromes
The primary pathological mechanism for paraneoplastic neurological syndromes is believed to be a form of onconeural immunity where the cancer causes a cross-immune reaction with the neurons. In a previous study, using a proteomic approach, we detected an anti-brain-type creatine kinase antibody that was associated with paraneoplastic cerebellar degeneration. Using immunohistochemistry, we showe...
متن کاملPemphigus.
Pemphigus vulgaris and paraneoplastic pemphigus are 2 subtypes of pemphigus that involve the oral mucosa. These autoimmune blistering disorders have antibodies targeted against proteins of keratinocyte adhesion, thereby causing acantholysis. Clinical findings include oral erosions and flaccid cutaneous bullae and erosions. Further malignancy workup in patients with suspected paraneoplastic pemp...
متن کاملSeroepidemiology and molecular detection of Brucella infection in Iranian horses: Aprovincial study
BACKGROUND: Brucellosis is a febrile zoonotic infectionand has worldwide distribution among humans as well asanimals. Although the seroprevalence of brucellosis in variousanimals has been described in Iran, there is only one report onequine brucellosis in the region. OBJECTIVES: This study wascarried out to determine the seroprevalence of brucellosis inracing clubs and private horse owners in t...
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